Chemical Name
Metanesulfonamide, N-(4-nitro-2-phenoxyphenyl)
Nimesulide is a relatively COX-2 selective, non-steroidal anti-inflammatory drug (NSAID) with pain medication and fever reducing properties. Its approved indications are the treatment of acute pain, the symptomatic treatment of osteoarthritis and primary dysmenorrhoea in adolescents and adults above 12 years old.
Medical uses
- Nimesulide is similar in gastrointestinal safety to other NSAIDs.
- It may be taken through prescription in the treatment of acute (short term) pain, and primary dysmenorrhea (period pains). Nimesulide should never be taken long-term, such as for chronic conditions like arthritis. This is due to its association with an increased risk of liver toxicity, including fulminant hepatic failure.
Side effects
Continuous use of nimesulide (more than 15 days) can cause the following side effects:- Diarrhea
- Vomiting
- Skin rash
- Pruritis
- Dizziness
- Bitterness in mouth
Due to concerns about the risk of hepatotoxicity, nimesulide has been withdrawn from market in several countries (Spain, Finland, Belgium and Ireland).
Availability
It is available in a variety of forms: tablets, powder for dissolution in water, suppositories, mouth dissolving tablets and topical gel.
A recent evaluation from the European Medicines Agency (EMA) concluded that the overall benefit/risk profile of nimesulide is favourable and in line with that of the other NSAIDs such as diclofenac, ibuprofen, and naproxen.
Top Brands Of Nimesulide
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